Rising KashmirRising KashmirRising Kashmir
  • Home
  • Top Stories
  • News
    • Kashmir
    • City
    • Jammu
    • Politics
  • Health
  • Anchor
  • Features
  • Interview
  • Video
Search

Archives

  • May 2025
  • April 2025
  • March 2025
  • February 2025
  • January 2025
  • December 2024
  • November 2024
  • October 2024
  • September 2024
  • August 2024
  • July 2024
  • June 2024
  • May 2024
  • April 2024
  • March 2024
  • February 2024
  • January 2024
  • December 2023
  • November 2023
  • October 2023
  • September 2023
  • August 2023
  • July 2023
  • June 2023
  • May 2023
  • April 2023
  • March 2023
  • February 2023
  • January 2023
  • December 2022
  • November 2022
  • October 2022
  • September 2022
  • August 2022
  • July 2022
  • June 2022
  • May 2022

Categories

  • Anchor
  • Breaking
  • Business
  • City
  • Developing Story
  • Editorial
  • Education
  • Features
  • Health
  • Interview
  • Jammu
  • Jammu and Kashmir News
  • Kashmir
  • Kashmir Tourism
  • Kath Bath
  • National
  • Opinion
  • Politics
  • Sports
  • Technology
  • Top Stories
  • Trending
  • Uncategorized
  • Video
  • Viewpoint
© 2022 Foxiz News Network. Ruby Design Company. All Rights Reserved.
Reading: Triple-Negative Breast Cancer: Characteristics, Treatment Options, and Emerging Therapies
Share
Notification Show More
Font ResizerAa
Rising KashmirRising Kashmir
Font ResizerAa
  • Home
  • Top Stories
  • News
  • Health
  • Anchor
  • Features
  • Interview
  • Video
Search
  • Home
  • Top Stories
  • News
    • Kashmir
    • City
    • Jammu
    • Politics
  • Health
  • Anchor
  • Features
  • Interview
  • Video
Follow US
© 2024. All Rights Reserved.
Rising Kashmir > Blog > Opinion > Triple-Negative Breast Cancer: Characteristics, Treatment Options, and Emerging Therapies
Opinion

Triple-Negative Breast Cancer: Characteristics, Treatment Options, and Emerging Therapies

DR. MANASI SHAH
Last updated: September 11, 2023 9:54 pm
DR. MANASI SHAH
Published: September 11, 2023
Share
4 Min Read
SHARE

One of the most complex cancers in the world remains breast cancer that affects millions of women globally. There are several subtypes and one of them that everyone must be aware of is the Triple-Negative Breast Cancer also known as TNBC. This cancer stands out as characterized by its aggressive behavior and limited treatment options.

 

Understanding what Triple-Negative Breast Cancer is

Triple-negative breast cancer is quite challenging considering the absence of three key receptors: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). This lack of receptors makes traditional hormone-based therapies ineffective, and hence making the disease unique.

 

What are the Characteristics of TNBC

TNBC is notorious for its aggressive nature, often presenting at a younger age and with a higher grade compared to other breast cancer subtypes. The absence of hormone receptors and HER2 amplification leaves fewer targeted treatment options, necessitating a comprehensive approach involving surgery, chemotherapy, and radiation. Its early metastatic potential further underscores the urgency to better understand this subtype and develop novel treatment strategies.

 

Current Treatment Options

  • Chemotherapy: Given the lack of targeted therapies, chemotherapy remains the cornerstone of TNBC treatment. Anthracyclines and taxanes have demonstrated efficacy, but the journey is fraught with potential side effects that clinicians and patients must carefully balance.
  • Surgery and Radiation: Surgical resection of the tumor, often followed by radiation therapy, plays a pivotal role in local disease control. However, the high propensity for recurrence demands a multi-pronged approach to ensure long-term survival.
  • Immunotherapy: Recent breakthroughs in immunotherapy have provided a glimmer of hope. Immune checkpoint inhibitors, such as PD-1/PD-L1 inhibitors, have shown promise in a subset of TNBC patients, rekindling optimism for targeted therapies.

 

What are the Emerging Therapies and Future Directions?

  • There are different therapies that can be looked at which include-
  • PARP Inhibitors: Poly (ADP-ribose) polymerase (PARP) inhibitors have shown remarkable potential in treating TNBC patients with BRCA mutations. These inhibitors exploit DNA repair deficiencies, leading to synthetic lethality in cancer cells.
  • Targeting Immune Microenvironment: Strategies aimed at enhancing the immune response within the tumor microenvironment are being explored. Combining immunotherapy with other agents like chemotherapy or targeted therapies holds the promise of unleashing potent anti-tumor immunity.
  • Novel Targeted Therapies: Researchers are diligently investigating new targets within TNBC cells that could be exploited for therapeutic purposes. From targeting specific signaling pathways to exploring gene expression patterns, these efforts aim to uncover vulnerabilities unique to TNBC.
  • Personalized Medicine: The era of personalized medicine is dawning upon us, with advances in genomics allowing for tailored treatment regimens. Identifying genetic alterations and molecular signatures can guide treatment decisions, optimizing therapeutic outcomes.

 

Triple-Negative Breast Cancer causes significant challenges to patients, doctors, and researchers because of its aggressive behavior and limited treatment options. As we stand on the cusp of a new era in cancer therapy, the convergence of immunotherapy, targeted treatments, and personalized medicine offers a renewed sense of optimism. Through collaborative efforts and relentless research, we inch closer to transforming TNBC from a mystery into a conquerable adversary, ushering in an era of improved outcomes and a brighter tomorrow.

 

 

 

(The Author is Consultant- Medical Oncology, HCG Cancer Centre, Ahmedabad)

Domestic Violence: An Exploitation and Spiteful Crime against Women
Can Yoga Prevent Kidney Disease?
Challenges of Marrying at Late Age
World Mental Health Day: “It is Time to Prioritize Mental Health in the Workplace”
Vitiligo: An issue to address

Sign Up For Daily Newsletter

Be keep up! Get the latest breaking news delivered straight to your inbox.
By signing up, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy. You may unsubscribe at any time.
Share This Article
Facebook Whatsapp Whatsapp Copy Link Print
Previous Article Violence against women
Next Article Role of Edible Bugs in achieving Zero Hunger by 2030
Leave a Comment Leave a Comment

Leave a Reply Cancel reply

Your email address will not be published. Required fields are marked *

Stay Connected

1MFollowersLike
262kFollowersFollow
InstagramFollow
234kSubscribersSubscribe
Google NewsFollow

Latest News

CM Omar Abdullah visits GMC Jammu 
Breaking
May 9, 2025
BCCI suspends IPL 2025 amid India-Pakistan tensions: Sources
Breaking
May 9, 2025
Deputy CM Surinder Choudhary reviews security, hospital arrangements in Rajouri
Breaking
May 9, 2025
Defence Minister Rajnath Singh holds review meeting at South Block amidst escalating tensions
Developing Story
May 9, 2025

Recent Posts

  • CM Omar Abdullah visits GMC Jammu 
  • BCCI suspends IPL 2025 amid India-Pakistan tensions: Sources
  • Deputy CM Surinder Choudhary reviews security, hospital arrangements in Rajouri
  • Defence Minister Rajnath Singh holds review meeting at South Block amidst escalating tensions
  • China “concerned” over current developments, urges India and Pakistan to exercise restraint

Recent Comments

  1. SavePlus on AI and Behavioural Analytics in Gaming: Making the World of Gaming Better
  2. Parul on Govt acknowledges faulty streetlights on Narbal-Tangmarg road
  3. dr gora on Women Veterinarians and the Goal of Viksit Bharat
  4. jalwa game login on National Education Policy 2020: Transforming India’s Educational System
  5. Virender Bhat on Pahalgam Attack: A War on Humanity, Peace, and Kashmiriyat

Contact Us

Flat No 7,Press Enclave, Srinagar, 190001
0194 2477887
9971795706
[email protected]
[email protected]

Quick Link

  • E-Paper
  • About Us
  • Contact Us

Top Categories

Stay Connected

1.06MLike
262.5kFollow
InstagramFollow
234.3kSubscribe
WhatsAppFollow
Rising KashmirRising Kashmir
Follow US
© 2025. All Rights Reserved.
Welcome Back!

Sign in to your account

Username or Email Address
Password

Lost your password?